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Drug or Drug Class Effect Calcium Carbonate Ferrous Sulfate Calcium carbonate may form an insoluble chelate with levothyroxine, and ferrous sulfate likely forms a ferric-thyroxine complex. How to synthroid Take, levothyroxine or Synthroid is usually taken orally through a pill, without food. Phenytoin and carbamazepine reduce serum protein binding of synthroid levothyroxine, and total and free T4 may be reduced by 20 to 40, but most patients synthroid have normal serum TSH side levels and are clinically euthyroid. Monitoring TSH and/or synthroid Thyroxine (T4) Levels Assess the adequacy of therapy by periodic assessment of laboratory tests and clinical evaluation. Antidepressant Therapy Concurrent use effects of tricyclic (e.g., amitriptyline) or tetracyclic (e.g., maprotiline) antidepressants and Synthroid may increase the therapeutic and toxic effects of both drugs, possibly due to increased receptor sensitivity to catecholamines. What other drugs will affect Synthroid? 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Do not share this medicine with another person, even if they have the same symptoms you have. While the general aim of therapy is to normalize the serum TSH level, TSH may not normalize in some patients due to in utero hypothyroidism causing a resetting of pituitary-thyroid feedback. Therefore, careful observation is needed when intravenous epinephrine is given to patients receiving levothyroxine who also have coronary effects artery disease. Call your doctor at once if you have: irregular heart rate; chest pain, feeling short breath; fever, hot flashes, sweating; feeling unusually cold; weakness, tiredness, sleep problems (insomnia effects memory problems, feeling depressed or irritable; headache, leg cramps, muscle aches;. Overtime, levothyroxine has been one of the most prescribed medications in the United States of America, when it comes to thyroid disorders. Levothyroxine is generally continued for life in these patients. 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Phenobarbital increases L-thyroxine metabolism by inducing uridine (UGT) and leads to a lower T4 serum levels. When drug interactions occur, this could lead to some horrible side effects or may change the entire make-up of the drug itself. Adverse Reactions Instruct patients to notify their healthcare provider if they experience any of the following symptoms: rapid or irregular heartbeat, chest pain, shortness of breath, leg cramps, headache, nervousness, irritability, sleeplessness, tremors, change in appetite, weight gain or loss, vomiting, diarrhea. Table 6 provides a listing of the color additives by tablet strength: Table. If the body does not naturally fix the problem, this is where medication can come synthroid into play. Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in children with resultant compromised adult height. 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